目的 采用两种吸收模型考察冰片对绿原酸口服吸收的促进作用并对模型间的研究结果进行相关性评价。方法 首先采用大鼠原位灌注模型考察冰片对绿原酸的肠道吸收是否具有促进作用,然后利用整体动物模型进行验证,并对两种模型得到的吸收参数进行相关性评价。结果 大鼠原位灌注模型中,合用冰片后,绿原酸吸收速率常数为0.083 4 h^-1,比单用绿原酸组的吸收速率常数增加1.58倍;整体动物实验表明,绿原酸灌胃给药后,体内过程符合二室模型,合用0.04%冰片后,最大血药浓度略有增加,相对生物利用度达到116.02%;相关性研究表明,两种模型的研究结果呈正相关,r=0.941,研究结果可靠。结论 冰片对绿原酸的口服吸收具有促进作用。

OBJECTIVE To investigate the enhancing effect of borneol on the absorption of chlorogenic acid (CGA) with two different biological models and to evaluate the correlation of these two models. METHODS The in situ rat perfusion model was used to investigate the enhancing effect of borneol on the absorption of CGA. The in vivo pharmacokinetics study was carried out to evaluate the correlation of the two-compartment open model.RESULTS With the in situ rat perfusion model, the absorption rate constant (Ka) of CGA was 0.083 4 h^-1,which was up to 1.58-fold higher by borneol. The results of in vivo pharmacokinetics study in rats suggested that 0.04% borneol could increase the relative bioavailability by 116.02% and maximum plasma concentration increased slightly. The consistent result of these two different absorption models was provided (r＝0.941). CONCLUSION Borneol could promote the oral absorption of CGA.